More like Man vs. Machine

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Stranger in a Strange LandNovel
Robert A. Heinleinstandalone novel1961
First contact, about aliens and faith and religion, set in north america.
Stand on ZanzibarNovel
John Brunnerstandalone novel1968
Dystopia, about genetic engineering and surveillance, set in big city.
The Light of Other DaysNovel
Arthur C. Clarke & Stephen Baxterstandalone novel2000
Time travel, tense in tone, about surveillance.
“An industrialist devises a technique to use tiny wormholes as light pipes to enable viewing of any event anywhere; and subsequently it becomes possible to use them to view any event in the past as well.”
from the catalogue
Childhood's EndNovel
Arthur C. Clarkestandalone novel1953
First contact, bittersweet in tone, about aliens and identity.
GenesisNovel
Bernard Beckettstandalone novel2006
Dystopia, about identity.
Blood MusicNovel
Greg Bearstandalone novel1985
Hard science fiction, about genetic engineering and nanotechnology, set in north america.