Watchers

This probably qualifies as a science-based adventure rather than a science fiction novel. The premise, and only speculative fiction element, is that a U.S. government funded laboratory creates a golden retriever that's as intelligent as a human for use in intelligence gathering and also creates a monkey hybrid that's intended for a military police dog role and as a killing machine on battlefields. The animals escape and the story plays out as a straight adventure novel with a good chunk of romance thrown in.