More like The River

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FootfallNovel
Larry Niven & Jerry Pournellestandalone novel1985
Alien invasion and first contact, about aliens, set in our world.
“When aliens travel to Earth from Alpha Centauri, differences between alien and human psychology result in an unprovoked invasion, and the resulting resistance results in the aliens' use of a devastating weapon.”
from the catalogue
The Andromeda StrainSeries
series2 books1969
About plague and pandemic.
“Daniel H. Wilson's authorized 2019 sequel The Andromeda Evolution revisits the same threat five decades later.”
from the catalogue
Start with The Andromeda Strain →
Hellstrom's HiveNovel
Frank Herbertstandalone novel1973
Eerie in tone, about surveillance and totalitarianism.
WatchersNovel
Dean R. Koontzstandalone novel1987
Adventure, about genetic engineering.
“The animals escape and the story plays out as a straight adventure novel with a good chunk of romance thrown in.”
from the catalogue
MidnightNovel
Dean R. Koontzstandalone novel1989
Horror, dark in tone, about genetic engineering, set in small town.
“A wealthy tech entrepreneur, intending to create superhumans by infecting them with nanotech to assist their physical and mental abilities, picks a California town as his secret pilot project, but things go terribly wrong.”
from the catalogue
The Puppet MastersNovel
Robert A. Heinleinstandalone novel1951
Alien invasion, about aliens, set in mid 20th century.
“Parasitical aliens attach themselves to human hosts and take over their bodies.”
from the catalogue